Endocrine Abstracts

Introduction: Hyponatremia is common in the emergency room, albeit frequently overlooked. Our objective was to describe the characteristics of hyponatremia in a cohort of emergency room patients, and evaluate how hyponatremia was studied and followed up.Material and methods: We studied all 211 patients under 70 years-of-age who presented/developed non-translocational hyponatremia (serum sodium (SNa) <135 mmol/l) during the first 48 h of their stay at...

Introduction: Controversy exists regarding type 2 diabetes (T2D) remission rates after bariatric surgery (BS) due to heterogeneity in its definition and patients’ baseline features. We evaluate T2D remission using recent criteria, according to preoperative characteristics and insulin use.Materials and methods: Retrospective study from a cohort of 657 BS performed in a single centre (2006–2011) of which 141 (57.4% women) had T2D. Evaluation of a...

Introduction: Remission of type 2 diabetes (T2D) is a yearned outcome after bariatric surgery (BS). Attention to individuals who do not strictly fulfil remission criteria has been frequently left behind. The aim of this study was to evaluate metabolic control status in patients considered as diabetes ‘non-remitters’.Materials and methods: Retrospective study of 125 patients (59.2% women) with preoperative diagnosis of T2D who underwent BS in a ...

Introduction: The contrast agents iopanoic acid and ipodate are potent inhibitors of thyroid function, reducing type I deodinase T3 generation, inhibiting thyroid liberation of T4 and T3, and T3 receptor binding, with off-label use in hyperthyroid emergencies. However, since the interruption of iopanoic acid production this year, neither agent is currently available in Spain.Case report: A 34-year-old male was ...

Introduction: Control of hypertension (HT) is essential to reduce cardiovascular events in diabetic patients (DPts). However, studies indicate that only 50% of DPts with treated hypertension present adequate blood pressure (BP) control. Yet Endocrine-Society-Guideline (ESG) screening for primary hyperaldosteronism (PHA) is rarely applied. Furthermore, in patients with essential hypertension (EH), longer-acting hypertension medication (HM) improves 24-hour BP when compared to r...

Introduction: Tolvaptan is the only V2-receptor antagonist authorized for use in Europe in patients with SIADH. Its initiation requires hospitalization. Our goal was to analyze the safety and efficacy of tolvaptan started in a Hospital Day-Ward.Material and methods: Retrospective descriptive study of 33 ambulatory patients with mild/moderate SIADH-induced chronic sustained hyponatremia initiating tolvaptan therapy in the Day-Ward of a tertiary center ove...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) can present a high morbi-mortality.Initial subtype identification facilitates appropriate management.We describe the utility of diagnostic tests in a cohort of patients with AIT.Material and methods: Retrospective, observational study of 59 patients attended from 2007 to 2018 in outpatient clinic. Differential diagnosis: type I if FT4 and FT3 (TH) were normalized following therapy with antithyroid dru...

Low-renin hypertension (LRH) with normal or elevated aldosterone levels is considered part of the spectrum of aldosterone-associated hypertension, and can cause poorly-controlled hypertension. We studied patients diagnosed with LRH, comparing their clinical and biochemical characteristics with patients diagnosed with primary hyperaldosteronism (PHA). Methods Retrospective. Diagnosis in a general Endocrinology out-patient clinic ove...

Acquired Hypoaldosteronism may be caused by low circulating aldosterone levels (AD), resistance to mineralocorticoid action (MR), or a combination of both (CB). We describe the clinical/biochemical characteristics of these three types of hypoaldosteronism. Methods Retrospective review of a series of 177 patients with acquired hypoaldosteronism assessed by the Endocrinology Department of a tertiary teaching hospital from 2012 to 201...

Background and Objective: Gestational Diabetes Mellitus (GDM) is associated with life-long adverse outcomes for the mother and the baby. To date there is no rigorous clinical test for the assessment of GDM risk, since estimation of GDM risk is currently primarily based on clinical risk factors. Additional markers are needed to identify women at high risk. Our aim was to develop and validate a risk assessment model to identify women at high risk of GDM through an algorithm that...